Age-Related Response to Heparin in Children.

Grant number: 454385 | Funding period: 2007 - 2010

Completed

Abstract

Unfractionated Heparin (UFH) is the most commonly used anticoagulant (blood thinning drug) in children. Despite this, the clinical evidence, in terms of reported treatment failures and bleeding complications, suggests the drug is used suboptimally in children compared to adults.This likely relfects the lack of specific studies of UFH in children. This study will, for the first time, define the pharmacokinetics-dynamics of UFH in children, allowing age-specific protocols to be developed. Pharmacological modelling of this data will likely have implications for the use of other anticoagulants in children.

Related publications (8)

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Novel interactions between UFH and TFPI in children

F Newall, L Johnston, R Summerhayes, G Lane, N Cranswick, P Monagle, V Ignjatovic

2010-11-01

The impact of age upon therapeutic response to unfractionated heparin (UFH) in children is proposed to reflect quantitative and po..

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Age-specific differences in binding of heparin to plasma proteins

V Ignjatovic, E Straka, R Summerhayes, P Monagle

2010-06-01

Background: Clinically significant age-related differences in the anticoagulation effect of heparin have previously been establish..

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An automated anti-IIa assay to measure UFH levels in plasma - A method without exogenous antithrombin

RG Summerhayes, F Newall, P Monagle, V Ignjatovic

2010-04-01

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Age is a determinant factor for measures of concentration and effect in children requiring unfractionated heparin

F Newall, V Ignjatovic, L Johnston, R Summerhayes, G Lane, N Cranswick, P Monagle

2010-01-01

Previous studies investigating continuous unfractionated heparin (UFH) therapy report age-related differences in UFH response in c..

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Clinical use of unfractionated heparin therapy in children: Time for change?: Research paper

F Newall, V Ignjatovic, L Johnston, R Summerhayes, G Lane, N Cranswick, P Monagle

2010-01-01

Paediatric recommendations for unfractionated heparin (UFH) management are extrapolated from adult trials, a practice that may con..

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Age-related plasma reference ranges for two heparin- Vinding proteins - Vitronectin and platelet factor 4

F Newall, L Johnston, V Ignjatovic, R Summerhayes, P Monagle

2009-12-01

This study was conducted to establish age-related reference ranges for two heparin-binding proteins - vitronectin and platelet fac..

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Refinement and feasibility testing of a manual micro-method for protamine titration

F Newall, L Johnston, V Ignjatovic, R Summerhayes, P Monagle

2009-08-01

Summary Current clinical recommendations for unfractionated heparin (UFH) therapy suggest target APTT ranges should reflect hepari..

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In vivo age dependency of unfractionated heparin in infants and children

F Newall, V Ignjatovic, R Summerhayes, A Gan, W Butt, L Johnston, P Monagle

2009-03-01

Introduction: Unfractionated Heparin (UFH) is used widely in paediatrics. Paediatric specific recommendations for UFH therapy are ..

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